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To investigate the result of IKK2 inhibitor VIII (HY-13060, Medchem Express, Monmouth Junction, NJ) on OA progress, MLI surgeries were carried out in twelve-week-outdated C57BL/six WT mice. The mice had been injected with IKK2 inhibitor VIII (two mg/kg, IP) just about every alternate working day for 5 months. OARSI scoring was executed by blinded

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